Read The FSSP Acceleration Toolkit For Topology Concerns

I have been getting more and more questions within the FSSP (ForeFront Security for SharePoint) space. If you are wondering about topology designs or where FSSP might live within a particular SharePoint configuration, please read the following and it will more than likely answer your question:

Using the Acceleration Toolkit for Microsoft Forefront Security for SharePoint

I wrote it to be pretty god damn exhaustive.